Anna Botting joined Sky News in 1995 as a reporter, before moving into the studio to anchor the news. During the 1997 election Anna Botting shadowed Liberal Democrat leader Paddy Ashdown, day-in day-out, for the whole six weeks of the campaign. She was also the first journalist to arrive at Kensington Palace on the day Diana, Princess of Wales died.
Anna Botting also covered the death of Pope John Paul II and anchored coverage of the wars in Afghanistan and Iraq from the studio. She was presenting on air when Serbian leader Slobodan Milosevic was ousted from office. In Summer 2006, whilst anchoring from Israel, Anna Botting interviewed the British politician George Galloway about the Israel-Lebanon war. Galloway criticised Sky News, News Corporation and Anna Botting in person for being biased towards Israel.
Anna Botting notably won the Royal Television Society’s news presenter of the year award in May 2012 and became the second woman to do so; this followed her return from Japan and location anchoring work for Sky News following the tsunami of March 2011. She reported from Fukushima Nuclear Power Station and North West Honshu Island in the aftermath of the disaster. Anna Botting also anchored on location during the fall of Tripoli in 2011.
Anna Botting had notably worked alongside the former Sky presenter Bob Friend before her popular partnership with Jeremy Thompson on Live at Five took off. Anna Botting appeared as herself in the 2014 science fiction action film Edge of Tomorrow, which stars Tom Cruise and Emily Blunt.